High uric acid level in blood

By on February 13, 2013
bood testing

High uric acid level in blood, a most common health problem found in new generation people

Hyperuricemia is an excess of uric acid in the blood. Uric acid passes through the liver, and enters your bloodstream. Most of it is excreted (removed from your body) in your urine, or passes through your intestines to regulate “normal” levels.

Normal Uric acid levels are 2.4-6.0 mg/dL (female) and 3.4-7.0 mg/dL (male).  Normal values will vary from laboratory to laboratory.

Also important to blood uric acid levels are purines.  Purines are nitrogen-containing compounds, which are made inside the cells of your body (endogenous), or come from outside of your body, from foods containing purine (exogenous).  Purine breaks down into uric acid. Increased levels of uric acid from excess purines may accumulate in your tissues, and form crystals. This may cause high uric acid levels in the blood.

If the kidneys do not eliminate the uric acid properly or if there is an excessive intake of high-purine foods, uric acid begins to crystallize. This crystallized uric acid settles in the kidneys and forms kidney stones or settles into joints and causes a form of arthritis called gout. Symptoms vary between individuals, depending on the severity of the condition. Some people with high levels of uric acid may not experience any symptoms.

Joint Symptoms

Common joint symptoms of gout include pain, inflammation, swelling, redness and tenderness when touched.  The joint may also feel hot. These symptoms usually begin suddenly at night.

Commonly Affected Joints

The first gout attack typically occurs in the big toe, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Additional joints in the body commonly affected by gout include the ankles, knees, heels, fingers, elbows and wrists. With the first gout attack, it is common for a person to experience symptoms in one joint, while subsequent attacks may involve more joints.

Duration of Joint Symptoms

The intense pain in the joint usually peaks in severity within the first 12 to 24 hours following the start of the symptoms. Once the most severe pain eases, discomfort in the joint may linger for several days to a few weeks. Attacks that occur later may cause pain to continue longer than the first gout attack. Without proper treatment or with repeated attacks, the uric acid may cause permanent damage to the joint.

Skin Symptoms

After years of repeated gout attacks, uric acid crystals may begin to form lumps beneath the skin. These nonpainful lumps, called tophi, commonly occur on the fingers, toes, hands and elbows. During an attack, the tophi may become swollen and tender.

Kidney Symptoms

If the uric acid crystals settle in the urinary tract, they cause kidney stones. Uric acid kidney stones are more common in men than women. Kidney stones may cause symptoms such as pain in the back, abdomen or groin, fever, chills, nausea, vomiting and bloody urine.

Causes of high uric acid level

A high uric acid level can be caused when your body either produces too much uric acid or your kidneys don’t eliminate uric acid rapidly enough.

A high uric acid level may cause increasingly frequent attacks of gout, or it may never cause problems. A high uric acid level may also cause some people to develop kidney stones or kidney failure. And some people with a high uric acid level also develop high blood pressure, heart disease or chronic kidney disease, but it’s often unclear whether this is a direct cause or merely an early warning sign of these conditions.

blood testing

Factors that may cause a high uric acid level in your blood include:

  • Diuretic medications (water pills)
  • Drinking too much alcohol
  • Genetics (inherited tendencies)
  • Hypothyroidism (underactive thyroid)
  • Immune-suppressing drugs
  • Niacin, or vitamin B-3
  • Obesity
  • Psoriasis
  • Purine-rich diet — organ meat, game meat, anchovies, herring, gravy, dried beans, dried peas, mushrooms and other foods
  • Renal insufficiency — inability of the kidneys to filter waste
  • Tumor lysis syndrome — a rapid release of cells into the blood caused by certain cancers or by chemotherapy for those cancers

Also, you may be monitored for high uric acid levels when undergoing chemotherapy or radiation treatment for cancer.

Foods that are high in purine include:

  • All organ meats (such as liver), meat extracts and gravy
  • Yeasts, and yeast extracts (such as beer, and alcoholic beverages)
  • Asparagus, spinach, beans, peas, lentils, oatmeal, cauliflower and mushrooms

New studies have proved that uric acid is a potent antioxidant

Over half the antioxidant capacity of human blood plasma is derived from uric acid. It is is fifty-fold stronger antioxidant than vitamin C. So, if we consider vitamin C to be a good player, we must consider uric acid as fifty times as good. Why is this fact not generally known? The answer: no drug company or medical journal profits from disseminating this information.

Uric Acid Facilitates Cross-talk Between Dead and Living cells

Uric acid is a principal endogenous danger signal released from dead and dying cells. This basic but generally unrecognized fact of uric acid biology calls for a major shift in the way we look at it. Uric acid stimulates a type of immune cell (dendritic cell) to its maturation. When such cells are injected along with certain substances in experimental animals, another type of immune cell (CD8+ T cell) becomes stronger in its responses to microbes and noxious chemicals. In other experiments, removal of uric acid weakens certain types of immune responses, indicating immune- boosting effects of uric acid.

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71 Comments

  1. Salim Venkitta

    February 13, 2013 at 12:04 pm

    Very informative and useful article…

    • salihu.salihu.ck

      February 14, 2013 at 1:27 am

      thanks for information.

  2. sherly

    February 13, 2013 at 11:57 pm

    a very good information to the public

  3. sumesh

    February 14, 2013 at 3:21 pm

    Really informative and to be followed by every one. Thankyou

  4. Manjar khan

    February 14, 2013 at 9:30 pm

    Thanks shareing important thing to us. i am suffering last two years URIC ACID problem i will try.

  5. yousuf

    February 15, 2013 at 1:56 am

    Very informative and useful article

  6. abdul mujeeb

    February 15, 2013 at 11:53 am

    Valuable information and advice.

  7. Dileep Kumar

    February 15, 2013 at 3:59 pm

    Dr,
    Thanks for ur valuable information and curing methods.

  8. raju

    February 16, 2013 at 11:40 am

    thnx

  9. salimkunju

    February 17, 2013 at 10:30 pm

    uric acid informatin thanks somach. plz mor need…,

  10. Shahul

    February 18, 2013 at 10:07 am

    Thank’s. good information.

  11. arunlal

    February 20, 2013 at 11:50 am

    Very good I have uricacid for past 4 years .how can I meet u

  12. Salini

    February 20, 2013 at 2:34 pm

    very informative article..

  13. cyril

    February 20, 2013 at 7:22 pm

    INFORMATIVE .Thank you

  14. faisal

    March 2, 2013 at 11:12 am

    Thanks for the infor..but still in cofusion regarding the mushroom…

  15. Dr Feminath

    March 2, 2013 at 5:58 pm

    very useful explaination

  16. afsal

    March 2, 2013 at 11:28 pm

    Thanks for ur informarion

  17. Anishkumar

    March 6, 2013 at 9:01 pm

    Uric acid information thnks somuch o need more tips reduce uric acid

  18. YasarArafath.M

    March 7, 2013 at 4:47 pm

    thanks ur information

  19. vinod k p

    March 7, 2013 at 5:50 pm

    many thanks for very helpfull information about uric acid problem, I need more tips reduce uric acid

    • ABDUSSAMAD KODINHI

      March 13, 2013 at 7:36 pm

      THANK U DOCTOR

  20. Hakkim

    March 13, 2013 at 7:06 pm

    very useful

  21. zulfikar

    March 14, 2013 at 11:36 pm

    thanks ur information

  22. moniaugustine

    March 15, 2013 at 12:46 pm

    very nice tips

  23. Tomy

    March 16, 2013 at 6:38 pm

    Thanks for your tips

  24. silvia

    March 16, 2013 at 7:15 pm

    thank u so much dr.

  25. Mathew joy

    March 17, 2013 at 9:12 am

    very good information

  26. shaiju zanobiya

    March 18, 2013 at 9:44 am

    verry goodinformation thanks

  27. ramkumar

    March 18, 2013 at 9:55 pm

    very help full

  28. fayis

    March 19, 2013 at 12:27 pm

    hanks for very helpful information

  29. shimnas

    March 19, 2013 at 1:42 pm

    Thanks goodinformation

  30. Winse

    March 19, 2013 at 4:55 pm

    Very informative report for me.Thank you. Have you treatment in Homeopathy for Uric acid?

  31. Noushad

    March 21, 2013 at 5:43 pm

    Thanks Doctor, good informations

    • amritha sara antony

      March 29, 2013 at 11:11 am

      thnku doctr .this s quite informative

  32. shajith

    March 21, 2013 at 7:14 pm

    thanks ur information

  33. cmali

    March 25, 2013 at 12:21 am

    Thanks for ur valuable information and curing methods.

  34. Binu anand

    March 25, 2013 at 3:57 pm

    Thank u very much doctor for this information ,I am a uric acid Patient last 4 years this information is very useful for me i will try these .

    Thanking you..

  35. Arakkal C. Hameed

    March 26, 2013 at 8:13 pm

    Really useful information….thanks a lot

  36. vasudevan

    March 26, 2013 at 9:47 pm

    very informative

  37. vasudevan

    March 26, 2013 at 9:49 pm

    very much informative

  38. jameer

    March 26, 2013 at 10:25 pm

    thank you very much for ur information

  39. shafeeq varikkottil

    March 27, 2013 at 12:11 am

    thanks for ur info

  40. saji

    March 27, 2013 at 7:29 pm

    thank you for useful info

  41. JOSE

    March 29, 2013 at 10:37 am

    good infro

  42. Deepa Venkitesh

    March 30, 2013 at 1:34 pm

    Thanks so much, now I know why my joints pain so much. Shared

  43. shain

    April 3, 2013 at 5:57 pm

    i am already doing it. found very effective. thank you very much

  44. bijujeyadevan@gmail.com

    April 3, 2013 at 9:28 pm

    thanks for ur info

  45. mohan

    April 7, 2013 at 6:19 pm

    good information,as i am a urci acid patiant.

  46. sharaf

    April 11, 2013 at 7:10 pm

    thanks 4 ur valuable information

  47. narayanan kottappurath

    April 13, 2013 at 10:12 am

    You are doing a great social work about social health awareness. Thanks from me and other beneficiaries.

  48. Salih bin usman

    April 15, 2013 at 4:09 pm

    Thanks for your valuable information

  49. haris k

    April 16, 2013 at 3:15 pm

    very gud info,thanq..i have same problem

  50. haris k

    April 16, 2013 at 3:46 pm

    very gud info,i have already this prblm….thanks

  51. Suhail

    April 30, 2013 at 10:08 am

    Useful information

  52. Twinkle Jose

    May 1, 2013 at 10:05 pm

    Thanks for giving such informations related to high uric acid level………..

  53. Smitha

    May 3, 2013 at 12:56 pm

    Thanks for the informative article. Uric acid issues are becoming more common these days due to unhealthy food habits.

    Your suggestions about the diet to follow for patients with high levels of Uric acid in blood is very helpful.

  54. Bipul Chandra Sarkar

    May 18, 2013 at 7:54 am

    thanks sir, for your nformation

  55. naserkp

    July 4, 2013 at 1:36 am

    very thanks

  56. Jaison

    July 14, 2013 at 4:22 pm

    Thanks a lot. Highly informative and useful for all looking up this subject.

  57. Aneesh Haridas

    July 17, 2013 at 10:18 am

    thank u for your correct information doc it`s help a lot

  58. farmees

    July 31, 2013 at 2:23 pm

    Thanks. .

  59. rana praveen

    July 31, 2013 at 9:37 pm

    thank u useful one!

  60. pravin

    August 13, 2013 at 11:36 am

    thanks u so much

  61. raju.s.r.

    November 18, 2013 at 12:22 pm

    very informative tips………thanks..

  62. Jaison

    April 20, 2014 at 12:24 pm

    I think Causes include high level of trigkycerrides and cholesterol

  63. pradeep

    August 18, 2014 at 1:21 am

    Very informative report thanx

  64. fysel

    September 29, 2014 at 9:25 pm

    Thanks for this valuable informations.

  65. siddikh

    November 17, 2014 at 1:37 am

    Very good information for especially uric acid patients

  66. ismal

    April 9, 2015 at 2:54 pm

    It is really use full information

  67. premachandran

    May 19, 2015 at 9:58 pm

    Thanks 4 the detailed information

  68. Abhilash

    June 21, 2016 at 9:50 am

    Thank you sir.. Good information

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